Antioxidants However, once again we take matters into hand and must emphasize that, like most else in this field,
Links to treatment ipo.. Cerovive is the registered tradmark of the astrazeneca corporation for the nxy-059, a derivative of pbn..
This is of some clinical importance, since an antiinflammatory pharmaceutical preparation rich in SOD stroke... astrazenca... stroke... astrazenca... ("orgotein") is used in veterinary medicine and recently has been shown to be both effective and apparently safe in the treatment of various inflammatory lesions in man. (1,138,154,165,177,184-194). Catalase has also been used in the treatment of arthritic disease in man with reported success. (195). Likewise, the action of such established antiflammatory drugs as the corticosteroids, (196) penicillamine,(197) and many non-steroidal antiinflammatory agents (1,76-183,198-200) may be at least partially dependent upon interference with active oxygen metabolism in phagocytes.
Further, peroxidase release from eosinophils may playa similar role in inhibition of the inflammatory response (201) while the antioxidant properties of ceruloplasmin may also give this compound antiinflammatory properties.(21,128).
An illustrative (albeit circumstantial) model for the role of superoxide in rheumatoid arthritis can be postulated as follows: Granulocytes tend to be concentrated at sites of active rheumatic disease, presumably in response to the presence of immune complexes and other immunomodulator substances. Superoxide, peroxide, and other active oxygen species produced further kindle the inflammatory process by specific mechanisms such as those outlined in Figure 4. Catalysis of radical oxidations by transition-sernies metals may also play a role. Agents such as ectopic SOD may interfere with this process by destroying active oxygen species or increasing peroxide fluxes, thus interfering with one or more of the mechanisms detailed above and in Figure 4.
Since SOD is one of the most substrate-specific enzymes known, at first sight its efficacy in rheumatoid arthritis and other lesions strongly implies a role for active oxygen species in such diseases and a role for superoxide-destroying agents in their treatment. However, there are serious problems with such an assumption. For example, the course of action of SOD as an inflammatory agent often bears no apparent relationship to its serum levels (1,185) and the "denatured" enzyme still possesses significant antiinflammatory properties. 185 Feel (51) even ably questions the specific role of the protein in destroying superoxide.
With this caution, active oxygen species may play a significant role in the etiology of other inflammatory lesions in man, For example, SOD is reported to be effective in the treatment of lupus erythematosis,(43,158) and unique light-activated, superoxide-dependent lymphocyte clastogenic factors present in the serum of patients with lupus and other collagen diseases may account for some of the photosensitivity of this group of disorders.(157-159).
Production of active oxygen species by activated phagocytes may also have a role in vascular (and other) damage following endotoxin shock,(144,145,205), burn-induced plasma volume loss (71) and even in atherosclerosis.(205). Similar mechanisms may account for the possible role of radical species in the progression of damage following neuronal injury.(14,17,56,171,206).